BackgroundRandomized controlled trials (RCTs) are often complex and expensive to perform. Less than one third achieve planned recruitment targets, follow-up can be labor-intensive, and many have limited real-world generalizability. Designs for RCTs conducted using cohorts and routinely collected health data, including registries, electronic health records, and administrative databases, have been proposed to address these challenges and are being rapidly adopted. These designs, however, are relatively recent innovations, and published RCT reports often do not describe important aspects of their methodology in (...) a standardized way. Our objective is to extend the Consolidated Standards of Reporting Trials (CONSORT) statement with a consensus-driven reporting guideline for RCTs using cohorts and routinely collected health data.MethodsThe development of this CONSORT extension will consist of five phases. Phase 1 (completed) consisted of the project launch, including fundraising, the establishment of a research team, and development of a conceptual framework. In phase 2, a systematic review will be performed to identify publications (1) that describe methods or reporting considerations for RCTs conducted using cohorts and routinely collected health data or (2) that are protocols or report results from such RCTs. An initial “long list” of possible modifications to CONSORT checklist items and possible new items for the reporting guideline will be generated based on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) and The REporting of studies Conducted using Observational Routinely-collected health Data (RECORD) statements. Additional possible modifications and new items will be identified based on the results of the systematic review. Phase 3 will consist of a three-round Delphi exercise with methods and content experts to evaluate the “long list” and generate a “short list” of key items. In phase 4, these items will serve as the basis for an in-person consensus meeting to finalize a core set of items to be included in the reporting guideline and checklist. Phase 5 will involve drafting the checklist and elaboration-explanation documents, and dissemination and implementation of the guideline.DiscussionDevelopment of this CONSORT extension will contribute to more transparent reporting of RCTs conducted using cohorts and routinely collected health data. (shrink)

Thomas Kuhn's The Structure of Scientific Revolutions has sold more than one million copies since its publication in 1962, is one of the most cited academic books of all time, and continues to be read and studied today. This volume of new essays evaluates the significance of Kuhn's classic book in its changing historical context, including its initial reception and its lasting effects. The essays explore the range of ideas which Kuhn made popular with his influential philosophy of science, including (...) paradigms, normal science, paradigm changes, scientific revolutions, and incommensurability; and they also look at less-studied themes in his work, including scientific measurement, science education, and science textbooks. Drawing on the latest scholarship as well as unpublished material in the Thomas Kuhn Archives at MIT, this volume offers a comprehensive way into Kuhn's philosophy and demonstrates the continuing relevance of his ideas for our understanding of science. (shrink)

Purpose: Josef Mitterer's essays are considered to be important philosophical advancements of radical constructivism. The main purposes of this paper are, on the one hand, to structure the RC landscape and, on the other hand, to investigate the relations of Mitterer's work to radical constructivism in particular and to philosophy in general. Findings: In this short essay focusing on Mitterer's Das Jenseits der Philosophie, I would like to stress two major points. First, Mitterer's book should be considered as one of (...) several contemporary variants of a radical critique of the semantic turn in the philosophy of science that has taken place since the mid-thirties with the works of Rudolf Carnap, Carl G. Hempel, Hilary Putnam, Alfred Tarski and others. Second, it is by no means clear how to determine the relevance of the new semantic critique for the present and future cognitive status of radical constructivism. The degree of relevance depends crucially on the use of the term "radical constructivism." If radical constructivism, as I will argue, is seen as an umbrella term for a group of empirical research programs, then, by sheer necessity, the relevance can be marginal only. If, however, radical constructivism is viewed as a special form of philosophy of language and/or as a new epistemology, then the importance of Josef Mitterer's approach must be judged within the context of available functional alternatives. Implications: An immediate consequence of this article lies in a renewed emphasis on advancing an empirical research agenda for radical constructivism and in an effective downsizing of radical constructivism as a philosophical perspective. (shrink)

Rudolf Leuckart’s 1851 pamphlet Ueber den Polymorphismus der Individuen stood at the heart of naturalists’ discussions on biological individuals, parts and wholes in mid-nineteenth-century Britain and Europe. Our analysis, which accompanies the first translation of this pamphlet into English, situates Leuckart’s contribution to these discussions in two ways. First, we present it as part of a complex conceptual knot involving not only individuality and the understanding of compound organisms, but also the alternation of generations, the division of labor in (...) nature, and the possibility of finding general laws of the organic world. Leuckart’s pamphlet is important as a novel attempt to give order to the strands of this knot. It also solved a set of key biological problems in a way that avoided some of the drawbacks of an earlier teleological tradition. Second, we situate the pamphlet within a longer trajectory of inquiry into part-whole relations in biology from the mid-eighteenth century to the present. We argue that biological individuality, along with the problem-complexes with which it engaged, was as central a problem to naturalists before 1859 as evolution, and that Leuckart’s contributions to it left a long legacy that persisted well into the twentieth century. As biologists’ interests in part-whole relations are once again on the upswing, the longue durée of this problem merits renewed consideration. (shrink)

The Russian poet and anthroposophist Andrei Belyi has four poems from 1918 with the same title, Anthroposophy [Antroposofiia]. These are love poems and anthroposophy is represented in them as a living spiritual being of female gender. The principal attribute of this being is a "clear gaze," "flashing eyes," which regard the poet from the precincts of light, of blueness, from waves of aromas and musical harmonies. These verses are clearly oriented to the poem "Three Encounters" [Tri vstrechi] by Vladimir Solov'ev, (...) the theme of which is the thrice-repeated vision of what Solov'ev recognized as the Sophia of the ancient Gnostics and of Jakob Böhme. How are we to understand Belyi's enigmatic poetic intent? How does anthroposophy—a "science of the spirit," an occult system created by Rudolf Steiner—become in Belyi's imagination now a "sister," now a beloved—"tender, gentle, and kind"—linked to the poet by a mysterious and fateful meeting in eternity? Most importantly, what does this anthropomorphism of anthroposophy mean? The suggestion that these verses may have had real prototypes poems does not eliminate the question. But the question is resolved if we turn to a very well-known and in certain respects key lecture by Steiner entitled "The Essence of Anthroposophy," which he gave in Berlin in February 1913, and which Andrei Belyi attended. This lecture not only provides the key to those of Belyi's poems of interest to us here; it also brings us directly to the theme of our present study, inasmuch as its content creates a bridge between Russian religious culture of the late nineteenth and the early twentieth centuries, developing under the aegis of Sophia, and the latest German gnosis. It is therefore worth dwelling on it especially. (shrink)

Rudolf Leuckart's 1851 pamphlet Ueber den Polymorphismus der Individuen (On the polymorphism of individuals) stood at the heart of naturalists' discussions on biological individuals, parts and wholes in mid-nineteenth-century Britain and Europe. Our analysis, which accompanies the first translation of this pamphlet into English, situates Leuckart's contribution to these discussions in two ways. First, we present it as part of a complex conceptual knot involving not only individuality and the understanding of compound organisms, but also the alternation of generations, (...) the division of labor in nature, and the possibility of finding general laws of the organic world. Leuckart's pamphlet is important as a novel attempt to give order to the strands of this knot. It also solved a set of key biological problems in a way that avoided some of the drawbacks of an earlier teleological tradition. Second, we situate the pamphlet within a longer trajectory of inquiry into part-whole relations in biology from the mid-eighteenth century to the present. We argue that biological individuality, along with the problem-complexes with which it engaged, was as central a problem to naturalists before 1859 as evolution, and that Leuckart's contributions to it left a long legacy that persisted well into the twentieth century. As biologists' interests in part-whole relations are once again on the upswing, the longue durée of this problem merits renewed consideration. (shrink)

In this paper Rudolf Carnap's definition of 'analytic truth' based upon a meaning postulate At, for theoretical predicates of a given scientific theory is subjected to critique. It is argued that this definition is both too exclusive and too inclusive. Assuming that the preceding is correct, At is subjected to further scrutiny to determine how to interpret it and whether, and under what conditions, it need even be true. It is argued that a given At need not be true (...) as a sentence in a scientific theory and that it must be regarded as a confusedly presented rule for the same. It is then argued that even as a semantical rule for the theory, At cannot provide a guarantee of truth for some meaning postulate similar to At in the theory itself. It is thus argued that Carnap's definition of 'analytic truth' for theoretical predicates is unsatisfactory. (shrink)

This imposing textbook bears the subtitle, "Readings in Metaphysics from Classical Philosophy to Existentialism," and appears to be uniquely designed for courses in metaphysics as taught in predominantly Catholic colleges and universities, although the selections reflect a distinct catholicity of concerns. In fact, when Bertrand Russell, A. J. Ayer and Rudolf Carnap get wind that some of their most polemical and positivistic pieces have been reprinted in a book of metaphysics, they are likely to reflect that Ecumenism has gone (...) too far. Their inclusion is justified, however, by the introductory assertion that "There is such a thing as antimetaphysical metaphysics, and empiricism specializes in this theory." But whatever the merits of this statement, the open-minded inclusion in this volume of spokesmen for "the opposition" is certainly to be applauded—the more so since this section contains a long and perceptive introduction by Jerzy Wojciechowski. Other sections of the book display classical and Christian thought on knowledge, being, God, potency and act; the dialectical tradition ; American pragmatism and naturalism ; and existentialism and phenomenology as represented by Heidegger, Sartre, Tillich, Marcel, Berdyaev and Buber. In addition to the generally good introductions to each of the five sections, the editors have provided glossaries of philosophical terms, lists of topics for discussions and term papers, and usually well-chosen "recommended readings."—H. P. K. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Response to David Carr, “The Significance of Music for the Promotion of Moral and Spiritual Value”Iris M. YobDavid Carr has addressed a question that has been lurking in philosophical literature for centuries and, I might add, in our collective intuition as well: Just what is the connection between music and the moral and spiritual life? And as we have come to expect from his work, he brings a (...) new perspective to this perennial question in his answer. First he traces a line of thinking since Plato about music and the ordering of the soul, he touches on the role of music and the other arts in exploring the complexities of the moral imperative as it is lived out in human lives, and returns at the end to give a new take on the old Platonic idea of ordering of the soul. Just maybe, he suggests, the detachment, however temporary, "from the trials and tribulations that beset us in the day to day rough and tumble of human practical affairs" "in the interests of some more balanced perspective" on spiritual and moral matters "might be easier to achieve in the contemplation and appreciation of great works of 'music alone.'"This conclusion does not lay claim to more than what is perfectly reasonable. Allowing oneself to be immersed in a great work of music or art or architecture or dance may very well provide that distance from every day life where one might [End Page 209] re-center and refocus, refresh and renew one's outlook on the world. Such an engagement with an artwork can interrupt the patterns of thinking and acting that might have become increasingly thoughtless and ego-centric. It can be a re-creation in the true sense of the word. Paul Tillich, one of the great twentieth century religious philosophers, tells of an experience he had during the First World War where he served as a chaplain in the German army. On a brief leave from the front he visited Kaiser Friedrich Museum in Berlin and stood entranced before Botticelli's "Madonna and Child with Singing Angels." The moment was spiritually transformative, he tells us, lifting his spirits beyond the mud and grime of the battlefield to contemplate life and meaning on a different plane altogether. The experience enabled him to return to duty with renewed inner strength and calm.1 I believe this is a rather powerful and compelling example of what Carr is talking about.In coming to his conclusion, Carr is relying on the particularly difficult case of "music alone," that is, music that does not have words, title, or any other kind of representative function. In other words his argument does not depend on any didactic nature or morally or spiritually directive intent of the music. Rather, it is centered on music that ostensibly is not about anything. This is musical sound composed and performed for the appreciation of what it is in itself. And yet, in providing distance from the every day world, according to Carr, it can give expression to "realms of spiritual experience that lie beyond the sensual and empirical." Here we enter the world of the metaphorical and symbolic, what Rudolf Otto would call the "irrational" or "superrational," or the realm of the Holy. While Carr does not state this explicitly I would go so far as to say that this realm of the wordless and sacred is where the spiritual and the moral are grounded and from where they draw their power.Against this background, I would like to ask how does "music alone," in the sense intended by Carr and Peter Kivy from whom he borrowed the term bring about this effect? We are unable now to ask Tillich what it was that gave the Botticelli its impact for him, but it is curious that what it did for him it most likely did not do for all the other soldiers from the front who happened upon it the way he did. Tillich would most likely explain its effect by resorting to his theory of symbols, because after all this painting does have a literal meaning that might very well have inspired him. But... (shrink)

Although now largely forgotten, the international language movement was, from the 1880s to the end of the Second World War, a matter of widespread public interest, as well as a concern of numerous scientists and scholars. The primary goal was to establish a language for international communication, but in the early twentieth century an increasing accent was placed on philosophical considerations: wanted was a language better suited to the needs of modern science and rational thought. In this paper, we examine (...) the example of the English scholar C.K. Ogden's international language Basic English and his efforts to win the Vienna Circle philosophers Otto Neurath and Rudolf Carnap over to the project. Basic is shown to be an implementation of key ideas in Ogden's philosophy of language, ideas shared to a large extent with Neurath and Carnap. This we see through an examination of their unpublished correspondence, as well as through the collaboration that emerged between Ogden and Neurath, in which Neurath's Isotype, a system for graphically representing statistical data, became closely aligned with Basic. Through the ideas and endeavours we investigate here, we gain a new perspective on this crucial period in the history of analytic philosophy. (shrink)

"Homage to Rudolph Carnap."--Hempel, C. G. Rudolf Carnap, logical empiricist.--Wedberg, A. How Carnap built the world in 1928.--Eberle, R. A construction of quality classes improved upon the Aufbau.--Carnap, R. Observation language and theoretical language.--Kaplan, D. Significance and analyticity: a comment of some recent proposals of Carnap.--Wójcicki, R. The factual content of empirical theories.--Williams, P. M. On the conservative extensions of semantical systems: a contribution to the problem of analyticity.--Winnie, J. A. Theoretical analyticity.--Wedberg, A. Decision and belief in science.--Bohnert, H. (...) G. Carnap's logicism.--Hintikka, J. Carnap's heritage in logical semantics.--Partee, B. H. The semantics of belief-sentences.--Kasher, A. Pragmatic representations and language-games.--Carnap, R. Notes on probability and induction.--Jeffrey, R. C. Carnap's inductive logic.--Hilpinen, R. Carnap's new system of inductive logic.--Kuipers, T. A. F. A generalization of Carnap's inductive logic. Essler, W. K. Hintikka versus Carnap.--Hintikka, J. Carnap and Essler versus inductive generalization.--Shimony, A. Carnap on entropy, introduction to "Two essays on entropy" by Rudolf Carnap. (shrink)